Johnny Depp joins an elite club of two-time SMA title holders (only Brad Pitt and George Clooney have matched the feat) as People's Sexiest Man Alive, having previously scored the honor in 2003.
"Johnny Depp has magical powers. He's unlike anyone else,” says actress Isla Fisher, who's married to Sacha Baron Cohen. "He’s funny, generous and clever. It’s just a shame he’s so hard on the eyes."
Visit PEOPLE.com for more on Depp and 109 other sexies - including Ryan Reynolds, Robert Pattinson, Jake Gyllenhaal, David Beckham, and more!